Kwang‐Yu Chang

Arsenic-endemic regions correlate with elevated tumor mutational burden and genomic alterations in urothelial carcinoma

Purpose: Urothelial carcinoma includes upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB). In Taiwan, the incidence of UTUC is disproportionately high. Environmental carcinogens such as arsenic may contribute to this pattern. This study aimed to...

Tumor-derived RPS19 engages C5AR1+ inflammatory macrophages to drive astrocyte reprogramming and glioblastoma progression

Glioblastoma (GBM) is an incurable brain tumor with poor survival outcomes. Its progression and recurrence are strongly influenced by infiltrative growth of tumor cells and tumor microenvironment (TME) components, particularly tumor-associated macrophages (TAMs). To identify pote...