Kwanghee Lee

( S )‐Pyrrolo[1,2‐ a ]pyrazine‐3‐carboxamide Analogs as Dual Akt/JNK Modulators With Antiproliferative Effects in MDA‐MB‐468 Cells

Triple‐negative breast cancer (TNBC) remains a major clinical challenge due to the absence of effective targeted therapies. In this study, thirty analogs of ( S )‐1‐oxo‐1,2,3,4‐tetrahydropyrrolo[1,2‐ a ]pyrazine‐3‐carboxamide ( A1 – F5 ) were designed, synthesized, and evaluated...