Kwang Yeon Hwang

AI-guided De Novo design of DHPS inhibitors

Hypusine modification of eIF5A by Deoxyhypusine Synthase (DHPS) is essential for the replication of a broad range of viruses, making DHPS an attractive host-directed therapy (HDT) target for antiviral drug discovery. AI-based drug design methods spanning binding affinity predicti...