Kun Leng

Regulators of interferon-responsive microglia uncovered by Genome-wide CRISPRi screening

Abstract Microglia dynamically support brain homeostasis through the induction of specialized activation programs or states. One such program is the Interferon-Responsive Microglia state (IRM), which has been identified in developmental windows, aging, and disease. While the func...

Increased synapse elimination by inflammatory cells contributes to long-lasting post-stroke memory dysfunction in old mice

Old patients are more likely to experience memory dysfunction than young patients after a stroke. It has been reported that brain astrocytes and microglia cause excessive removal of synapses at the acute and subacute stages of stroke, and inhibition of their phagocytosis improved...