Kubra F. Naqvi

SMURF2 inhibits autophagic control of Mycobacterium tuberculosis in macrophages

Abstract Autophagy is a critical host defense mechanism that restricts intracellular pathogens such as Mycobacterium tuberculosis (Mtb). A key step in this process is the ubiquitination of Mtb or Mtb-associated structures. The E3 ligase SMURF1 catalyzes K48-linked ubiquitination,...