Kripa N. Nand

The assembly pathway for human papillomavirus L1 capsid protein is encoded in electrostatic interactions

Human papillomavirus L1 protein spontaneously folds and assembles into 60 nm virus-like particles (VLP), with T = 7d icosahedral symmetry at high salt concentrations but not in low salt. Rapid increase from low to high salt during the assembly process gives poor-quality VLPs, whi...