Kozhinjampara R. Mahendran

A self-assembled peptide forms α-helical nanopores for ultrasensitive biomarker profiling

α-Helical nanopores are attractive molecular sensors, yet their rational design and assembly remain challenging. Here we show that the single peptide pPorA, derived from porin PorACj, self-assembles into flexible α-helical nanopores, inserts in lipid membranes and exists in disti...