Koen Van Laere

No significant changes in synaptic density and gray matter volume following motor learning—a pilot study

Abstract In animal neurophysiology, motor learning induces long-term potentiation- and depression-like plasticity. In humans, gray matter volume (GMV) changes, measured non-invasively by MRI, in response to motor learning are interpreted as a surrogate measure of plasticity. Here...

Multimodal Retinal Imaging for the Detection of Early Alzheimer’s Disease: Combining Biochemical, Structural, and Vascular Biomarkers

Alzheimer’s disease (AD) pathology is increasingly recognized to manifest in the retina, offering a non-invasive window for early biomarker discovery. This proof-of-concept study investigated whether multimodal retinal imaging—hyperspectral imaging (HSI), optical coherence tomogr...

Effects of motion and white matter hyperintensities on reference region based ¹⁸F-SynVesT-1 PET quantification in Alzheimer’s disease and healthy volunteers

18 F-SynVesT-1 is a PET tracer targeting synaptic vesicle protein 2A, a surrogate marker of synaptic density. Simplified quantification using pseudo-reference regions such as the centrum semiovale (CSO) or whole cerebellum (CER) has previously been validated in healthy volunteers...