Koen Braat

SRF fusion oncogenes encode constitutively activated chimeric transcription factors in myoid soft tissue tumors

ABSTRACT SRF fusion genes drive the pathogenesis of muscle-related soft tissue tumors, including subsets of perivascular tumors, inflammatory myofibroblastic tumor, and rhabdomyosarcoma. SRF encodes Serum Response Factor, a well-characterized transcription factor that regulates m...