Kieron May

Separable downmodulation of meiotic axis protein deposition and DNA break induction at chromosome ends

Abstract In many organisms, meiotic crossover recombination is suppressed near the extreme ends of chromosomes. Here we show that multiple, often chromosome-specific, suppressive mechanisms with differing ranges contribute to the consistently low enrichment of recombination-promo...

A tumour-derived organoid biobank maps cancer gene dependencies

Abstract Cancer cell lines remain foundational for research and drug discovery, yet they incompletely capture tumour diversity, lack linked patient context, and have undergone adaptation to culture. Tumour organoids are three-dimensional cultures derived from patient tissue that...