Kian R. Weihrauch

A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer

Abstract Small cell lung cancer (SCLC) is one of the most aggressive malignancies, characterized by rapid metastatic dissemination and poor overall survival. Despite harboring excessive alterations, expectedly resulting in immunogenic neoantigens, patients with SCLC remain largel...