Kian Fan Chung

Sputum eosinophil and neutrophil activation biomarkers in severe asthma

Background Asthma is characterized by different inflammatory phenotypes. We hypothesized that sputum eosinophil-derived neurotoxin (EDN), and myeloperoxidase (MPO) or interleukin-8 (IL-8) levels improves the granulocytic characterization of asthma compared to sputum granulocyte c...

Cellular, molecular and functional characteristics of induced pluripotent stem cell derived neurons from refractory chronic cough patients and healthy controls

The pathophysiology of refractory chronic cough (RCC) and the aetiology of associated cough hypersensitivity syndrome remains unclear, partly due to the absence of a suitable disease-specific sensory neuronal model. This study was designed to investigate whether induced pluripote...