Khushboo Sinha

Clinicopathological Implications of IDH1 Mutation and Ki-67 Expression Across WHO Grades of Gliomas: Insights from a Prospective Observational Study.

Background & Objective: Gliomas are heterogeneous central nervous system tumors with variable outcomes. Accurate classification using histopathological and molecular markers, such as IDH1 R132H mutation and Ki-67 index, is essential. This study evaluated their distribution across...

DIAGNOSTIC ACCURACY OF INTRAOPERATIVE SQUASH SMEAR CYTOLOGY IN CENTRAL NERVOUS SYSTEM LESIONS WITH HISTOPATHOLOGICAL CORRELATION AND IDH-1 IMMUNOHISTOCHEMICAL EXPRESSION IN ASTROCYTIC TUMOURS: A CROSS-SECTIONAL STUDY

Background: Intraoperative squash smear cytology provides rapid provisional diagnosis during neurosurgical procedures for central nervous system (CNS) lesions. Contemporary WHO classification of CNS tumours emphasizes integrated histomolecular diagnosis, with isocitrate dehydroge...