Khristina E. Young

Form and function of actin impacts actin health and aging

Abstract The actin cytoskeleton is a fundamental and highly conserved structure that functions in diverse cellular processes, yet its direct contribution to organismal aging remains unclear. Here, we systematically interrogated how genetic and pharmacologic perturbations of actin...

FGF21-dependent and -independent liver transcriptomic adaptations to low-protein feeding during aging

Aging is a risk factor for the development and progression of metabolic impairments. Dietary protein restriction (DPR) is protective against obesity- and age-related metabolic decline by the induction of the fibroblast growth factor (FGF21), which regulates body weight, lipid han...