Khaphetsi Joseph Mahasa

Quantifying immunosuppressive barriers using a mathematical framework of tumor-associated myeloid cell mediated resistance in oncolytic virotherapy

Oncolytic virotherapy (OVT) represents a promising frontier in oncology, utilizing engineered viruses to selectively lyse malignant tumor cells while simultaneously triggering a systemic anti-tumor immune response. However, the therapeutic efficacy of OVT is frequently hampered b...