Khaled A. Abdel-Sater

The glymphatic connectome: a hypothesis for how metabolic waste accumulation may contribute to preferential network degeneration

Background Neurodegenerative diseases exhibit selective vulnerability, with preferential involvement of highly connected brain regions. This review explores how glymphatic dysfunction and impaired extracellular waste removal may contribute to network-specific degeneration.Methods...

ACE2 at the neurovascular–glymphatic interface: integrating the ACE2/ang-(1–7)/mas axis with brain fluid homeostasis and waste clearance

Background and aim Brain fluid homeostasis relies on coordinated interactions among the glymphatic system, intramural peri-arterial drainage, meningeal lymphatics, cerebrospinal fluid circulation, and the neurovascular unit (NVU). Emerging evidence indicates that angiotensin-conv...