Keya Roy

Ball‐Milling‐Enabled Solvent‐ and Ligand‐Free Tsuji–Trost Reaction of C ‐, N ‐, O ‐, S ‐, and Se ‐Nucleophiles in Air: Synthesis and Late‐Stage Modification of Drugs

We report a novel ball‐milling‐enabled, ligand‐free Tsuji–Trost reaction involving C ‐, N ‐, O ‐, S ‐, and Se ‐nucleophiles with allyl and cinnamyl acetates, as well as allyl phosphate. Thiophenols and benzeneselenol have been demonstrated for the first time as nucleophiles in a...