Kevin S O'Connell

A GENOME WIDE ASSOCIATION ANALYSIS ON NITRENIUM-DERIVED CLOZAPINE METABOLITES – A STUDY WITH 306 SUBJECTS WITH KNOWN SMOKING STATUS

Background and aim Clozapine is the most effective antipsychotic for treatment of schizophrenia, yet its clinical use is limited by potentially life-threatening side effects including agranulocytosis and myocarditis. It has been suggested that bioactivation of clozapine to its re...