Kevin O’Leary

Macrophage Smad1 drives post-infarction dysfunction by reducing angiogenesis and by promoting matrix remodeling

AIMS: Infarct macrophages undergo dramatic phenotypic changes in response to cytokines and growth factors and serve as central effectors in cardiac repair and remodeling. Transforming Growth Factor (TGF)-β superfamily members are key regulators of macrophages and signal predomina...