Kevin D. Clark

Enzymatic Ligation Strategy to Enhance Electrospray Ionization Efficiency and Liquid Chromatography─Mass Spectrometry of DNA and RNA Oligonucleotides

Abstract Mass spectrometry (MS) is a powerful technique for characterizing modified RNA as it directly maps and quantifies all mass-altering modifications simultaneously. However, the physicochemical properties of RNA result in poor ionization efficiencies during electrospray ion...