Kesheng Fu

Structure-Guided Engineering of Amine Dehydrogenase for Chiral Bulky β -Aryl Amine Synthesis: Dynamic Loop-to-Helix Shift and Hydrogen-Bond Network Reconstruction

Abstract Chiral β-aryl amines are critical structural motifs in various bioactive compounds and pharmaceuticals. Amine dehydrogenases (AmDHs) offer a promising sustainable approach to catalyze the asymmetric reductive amination of β-aryl ketones to chiral β-aryl amines. However,...