Kenneth Michael Humphries

Triphenylphosphonium compounds preferentially inhibit long-chain fatty acid oxidation in cardiac mitochondria

Triphenylphosphonium (TPP) is a lipophilic molecule widely used in targeting compounds into the mitochondria. Despite its wide use, TPP has known mitochondrial toxicity, the characteristics of which are not completely defined. In this study, we sought to determine if the effects...

PFKFB2 Gates a Relationship Between Cardiac Glycolytic Regulation and Electrophysiological Function

Abstract Background The cardiac isoform of phosphofructokinase-2/fructose 2,6-bisphosphatase (PFKFB2) is the heart’s strongest glycolytic regulator but is degraded in the absence of insulin signaling. This makes PFKFB2 loss critical to understand in metabolic heart disease, of wh...