Kenju Shimomura

A novel SUR1‐TMD0 interaction region contributes to glucose‐dependent inhibition of pancreatic K ATP channels by bupropion

Background and Purpose Pancreatic β‐cell ATP‐sensitive potassium (K ATP ) channels play a central role in glucose homeostasis by coupling cellular metabolism to insulin secretion. Although conventional K ATP channel inhibitors are effective insulin secretagogues, their clinical u...