Keith R. Abrams

Meta-analysis and network meta-analysis of time-to-event outcomes with non-proportional hazards: a Bayesian time-varying hazard ratio approach

Abstract Background Meta-analyses of time-to-event (TTE) outcomes, particularly in Health Technology Assessment (HTA), commonly use a hazard ratio (HR) scale. However, non-proportional hazards in included trials create difficulties. Existing methods are either too complex or not...