Keith Fluegge

Clinical translation barriers of posttranslational scaffolding targets in Tsc1 conditional knockout models

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Deconstructing Simufilam: Resolving Forensic Investigations and Phase 3 Trial Failures via a Fragment Decoy Intercept Model

The clinical development of the small-molecule drug candidate simufilam marks one of the most controversial chapters in contemporary neuropharmacology. While the mainstream consensus interprets recent forensic investigations and Phase 3 trial failures as a complete invalidation o...