Keishi Fujio

CASTOR1 regulates humoral immune responses and contributes to the pathogenesis of systemic lupus erythematosus

Objectives CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. Methods We analyzed human B cell transcriptomes from healthy...