Keiji Sugiyama

Durable disease control following multidisciplinary treatment including pembrolizumab in POLE-mutated dedifferentiated endometrial carcinoma with brain metastases

Rationale: Dedifferentiated endometrial carcinoma (DEC) is a rare and aggressive subtype of endometrial cancer comprising undifferentiated carcinoma and a low-grade endometrioid component. Although POLE -mutated tumors usually show favorable outcomes owing to their ultramutated a...

Sex-based survival differences in patients with untreated advanced oesophageal squamous cell carcinoma receiving chemotherapy and immune checkpoint inhibitors: a meta-analysis

Purpose Chemotherapy combined with immune checkpoint inhibitors (ICIs) is the standard first-line treatment for patients with advanced oesophageal squamous cell carcinoma (OSCC). Evidence from other tumour types suggests that biological sex may influence ICI efficacy, but this re...