Keiji Numata

2-Aminoisobutylic Acid-Stabilized Helical Peptides for Selective Mitochondrial Gene Delivery

Abstract Efficient gene delivery to mitochondria remains a major challenge in the development of organelle-targeted therapeutics. Here, we report the rational design and evaluation of helix stabilized mitochondria-targeting peptides (MTPs) via the incorporation of 2-aminoisobutyr...

Development of a UV-Responsive Fusion Peptide Combining a Cell-Penetrating and a Mitochondria-Targeting Peptide to Suppress Intracellular Off-Target Effects

Abstract Modification of plant mitochondria has attracted increasing attention as a strategy for developing highly productive crops, driving efforts to achieve efficient mitochondrial delivery of cargos. Mitochondria-targeting gene carriers with a strong cell-penetrating ability...