Kazuya Kikuchi

Activity-Guided Identification of Pro-inflammatory Neutrophils with Dual Enzyme- and Metabolite-Activatable Fluorescent Probes

Abstract Neutrophils are the most abundant circulating leukocytes in the innate immune system. Primary neutrophils comprise multiple distinct subtypes that regulate antimicrobial defense and inflammatory diseases. Current fluorescent probes for imaging neutrophils cannot distingu...

pH-Responsive Probe for β-Lactamase-based Protein Tag in Fluorescence Imaging of Receptor Endocytosis

Abstract Fluorescence imaging of the local pH environment surrounding proteins offers an understanding of cellular processes, including receptor endocytosis. We herein develop a pH-responsive fluorescent β-lactamase inhibitor for protein labeling via a genetically encodable β-lac...