Kazunobu Ohnuki

Generation of hypoimmunogenic cardiomyocytes from human induced pluripotent stem cells with TAPBP knockout

Immunological rejection is a challenge for the transplantation of cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs). TAP-binding protein knockout (TAPBP-KO) hiPSC-derived CMs (hiPSC-CMs) were used to reduce human leukocyte antigen class I expression...