Kazuhiro Yagita

11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress

Abstract Glucocorticoids (GCs) have been proposed as maternal-fetal communication signals. However, fetal circadian rhythms are initially shielded from maternal entrainment, in addition to delayed circadian clock emergence due to CLOCK suppression. Premature CLOCK/BMAL1 activatio...