Kazuhiro Matsuoka

Divergent interfaces and convergent outcome in the structural basis of HIV-2 Vif antagonism of APOBEC3H

Abstract Primate lentiviruses counteract antiviral APOBEC3 (A3) cytidine deaminases through virion infectivity factor (Vif), which recruits A3 proteins to a Cullin–RING E3 ubiquitin ligase for proteasomal degradation. While HIV-1 Vif is well characterized, HIV-2 Vif remains poorl...