Kaustuv Sanyal

Marine chitinase BtChi disrupts cell wall integrity in Candida albicans and non-albicans species by chitin targeting and release of chitooligosaccharides

Abstract Increasing resistance to conventional antifungal drugs against Candida species, along with the limited availability of drug targets due to similarities between fungal and human cellular processes, necessitates alternative antifungal strategies. Chitin, a key polysacchari...

Terminator-dependent facilitated recycling of RNA polymerase III provides gene-specific transcriptional activation in vivo

Genes transcribed by the RNA polymerase (Pol) III of yeast are mostly found at sites of high transcription, genomic fragility, and replication fork stalling. Transcription terminator–dependent facilitated recycling of Pol III on naked DNA templates boosts transcription in vitro;...