Katrina H. Ruzicka

Synthesis and Application of 3,3-Difluoro Sialic Acid as a Sialyltransferase and Neuraminidase Inhibitor

Abstract Sialic acid (Neu5Ac) is a monosaccharide terminating glycoconjugates, serving as ligands for lectins in health and disease. Tools to target sialyltransferases (STs) and neuraminidases (NEUs) are important in the study of sialoglycans. 3FaxNeu5Ac is a common ST inhibitor,...