Kathryn S.E. Cheah

Integrated stress signaling pathways promote adaptive reprogramming for chondrocyte survival in Metaphyseal Chondrodysplasia Type Schmid

Abstract Collagen X, encoded by the Col10a1 gene, is expressed specifically by hypertrophic chondrocytes (HCs) in the cartilage. Mutations of the Col10a1 gene in humans, which increase the endoplasmic reticulum (ER) stress in HCs, lead to metaphyseal chondrodysplasia type Schmid...

β-Catenin Knockout in the Olfactory Bulb and Hippocampus Reveals Dual Roles in Olfactory Discrimination and Working Memory

Mice rely heavily on their sense of smell to provide crucial environmental information. The intricate organization of neural circuits within the olfactory bulb (OB) and the communication across the OB-hippocampus network in mice underpin their ability to discriminate and adapt to...