Katherine E. Irwin

Brain iron as a surrogate biomarker of pathological TDP-43 identifies brain region-specific signatures in aging, and disease

Abstract Background TDP-43 pathology is a defining feature of several neurodegenerative diseases, but its prevalence and regional distribution in aging and disease are not well characterised. We investigated molecular TDP-43 dysregulation across aging, Alzheimer’s disease (AD), a...