Katharina Ledebur

Sequence models reveal diagnosis accumulation pathways beyond comorbidity burden in population-scale hospital data

Aging trajectories vary among individuals of similar age and disease burden. Comorbidity indices, e.g. the Elixhauser index, summarize conditions cross-sectionally, but discard the timing, sequence, and pace of morbidity accumulation. Here we ask whether longitudinal hospital dia...

Characterization of diseases in temporal comorbidity networks

Comorbidity networks, or disease-disease networks, represent relationships between diseases and can reveal non-random disease associations and multimorbidity structure. These patterns reflect shared pathophysiology, diagnostic pathways, and risk of adverse outcomes. Using large-s...