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Prenatal bisphenol A exposure is associated with sex-specific cerebellar transcriptomic alterations and altered motor performance in rat offspring

Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by a significant male-to-female bias and cerebellar abnormalities. Although bisphenol A (BPA) has been increasingly investigated as a potential environmental risk factor, the molecu...

Prenatal BPA exposure is associated with a sex-stratified TF–RBP–Ccar1 splicing regulatory network, purkinje cell layer alterations, and transcriptomic concordance with PTEN I135L cerebellar organoid models

Autism spectrum disorder (ASD) is a pervasive neurodevelopmental condition characterized by social communication deficits and restricted, repetitive behaviors, exhibiting a consistent male bias in prevalence. Emerging evidence suggests that prenatal exposure to bisphenol A (BPA),...