Karma C. Fussell

Human myeloperoxidase-driven activation of skin sensitizing p-phenylenediamine-related aromatic diamines and phenylpropanoids–insights from in chemico and in silico approaches

Abstract Skin sensitization is initiated by the covalent binding of low-molecular-weight chemicals to skin proteins. For prehaptens, this requires oxidative activation to generate electrophiles capable of reacting with skin proteins. While abiotic oxidation is established, enzyma...