Karin Bornfeldt

Hyperglycemia Drives an Activated, Lipid-Laden Nonclassical Monocyte Phenotype in Diabetes

The presence of lipid-loaded macrophages in the artery wall and kidney characterizes diabetic atherosclerotic cardiovascular disease and diabetic kidney disease, respectively. Monocytes, the bone marrow–derived precursors of macrophages, accumulate lipids in response to hyperchol...