Karim Shamsasenjan

Mechanistic insights into the role of hypoxia-preconditioned mesenchymal stem cell-derived small extracellular vesicles in angiogenesis, adhesion, emt, and tumor progression in solid tumors

Solid tumors harbor a highly hypoxic tumor microenvironment (TME) that plays a pivotal role in tumor progression, therapeutic resistance, and metastasis. Mesenchymal stem/stromal cells (MSCs) are actively recruited into these hypoxic regions, where they undergo phenotypic reprogr...