Karam M. Chaaban

Colon cancer in a patient with a mosaic monoallelic germline pathogenic NF1 gene variant

Pathogenic variants in the tumor suppressor gene NF1 cause neurofibromatosis type 1 (NF1), one of the most common hereditary cancer predisposition syndromes. Pathogenic NF1 variants have been associated with an increased risk of several cancers; however, the relationship between...