Kara G. Lassen

Ontogenically distinct mouse alveolar macrophages modulate cigarette smoke-induced lung inflammation via Spp1

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death. While airway-recruited macrophages contribute to COPD pathogenesis, the role of embryonic alveolar macrophages (Em-AM) remains unclear. Using a cigarette smoke (CS)-induced COPD mouse model, we find...