Kannapiran Ponraj

The role of CYP3A-CYP2E1 interactions in activation of CYP3A enzymes by chronic alcohol exposure

To examine the effect of chronic alcohol exposure on the activity of CYP3A enzymes in human liver, we studied the metabolism of CYP3A-specific substrates 7-benzyloxyquinoline (7-BQ) and ivermectin in 23 preparations of human liver microsomes (HLM) obtained from donors with docume...