Kangbo Huang

Targeting NSUN5-mediated m5C-RNA modification overcomes sunitinib resistance in renal cell carcinoma by suppressing Fibronectin/PI3K/AKT signaling

Abstract Sunitinib resistance represents a dominating obstacle for clinical pharmacotherapy of renal cell carcinoma (RCC). Dysregulation of the RNA 5-methylcytosine (m 5 C) modification exerts an important influence on tumor pathogenesis, yet its role and the mechanism underlying...