Ka Lung Tsang

Structural insights into how metallochaperones UreE and UreG interact to deliver a toxic metal to urease

Abstract Maturation of urease, a virulence factor for Helicobacter pylori infection, requires the delivery of nickel ions to the metalloenzyme. To avoid cytotoxicity, nickel ions are transferred within protein complexes of metallochaperones to ensure that the toxic metal do not e...