Kendall N. Houk

Leveraging Cubenes to Access Highly Functionalized Fused Cubes

Abstract Since 1913, cubane has fascinated chemists owing to its remarkable structure. More recently, however, cubanes have emerged as attractive bioisosteres for aromatic rings. Although substituted derivatives are relatively common, ring-fused cubanes (a.k.a. “fused cubes”) are...

Adamantyl-BOX Ligand Enabling Stereoselective Synthesis of Axially Chiral Aldehydes Bearing Vicinal Stereogenic Centers

Abstract Biaryl frameworks combining axial and multiple central chiralities are highly valuable in synthesis and drug discovery. However, simultaneous construction of axial and vicinal central chiralities faces severe matching/mismatching limitations. Herein, we describe a dual p...