Juxiang Chen

Long survival in a TP53 germline-mutant glioblastoma with multi‑omics insights

Li-Fraumeni syndrome, caused by germline mutations in TP53 , is associated with a high lifetime risk of various malignancies, including Glioblastoma (GBM). Long-term survival in GBM is extremely rare, and the underlying biological mechanisms remain poorly understood, particularly...