Jürg Hafner

A TERRA-NONO axis drives fibroblast reprogramming in cancer

The molecular mechanisms linking chromosome homeostasis to fibroblast reprogramming into cancer-associated fibroblasts (CAFs) remain poorly understood. Here, we identify a clinically relevant, telomere-associated nuclear pathway driving CAF activation across multiple human cancer...

Severe, Therapy-Resistant Generalized Lichen Sclerosus with Morphea Overlap Successfully Treated with Intravenous Immunoglobulin and Type 1 Interferon Receptor Monoclonal Antibody Infusion: A Case Report

Introduction: Generalized extragenital lichen sclerosus with morphea overlap is a rare inflammatory and fibrosing dermatosis. Severe bullous-ulcerative disease remains therapeutically challenging and can cause major morbidity. Case Presentation: We report a 54-year-old woman with...