Junyan Zhu

TAMs-derived exosomal PD-L1 drives mitochondrial dysfunction and aberrant fatty acid oxidation via PGC-1α/PPARα axis to promote peritoneal metastasis in epithelial ovarian cancer

Tumor-associated macrophages (TAMs) are the most abundant immune cells in the ovarian cancer peritoneal microenvironment; however, how their exosomes metabolically reprogram CD8⁺ T cells to induce dysfunction and promote peritoneal metastasis remains unclear. M2-type TAMs were in...